Dear Colleagues,

The rising global population and increasing life expectancy have elevated chronic diseases to the forefront of global health, posing significant health, economic, and social challenges. Despite considerable overlap in clinical symptoms across chronic conditions, the underlying molecular and pathophysiological mechanisms can vary significantly between individuals. The one-size-fits-all approach adopted by traditional medicine has often proven inadequate in addressing the complexities of chronic illnesses, underscoring the urgent need for individualized care paradigm.

The identification of innovative biomarkers is pivotal for disease stratification, early diagnosis, and prognosis, while the discovery of novel therapeutic targets offers opportunities for tailored treatments that meet the unique needs of an individual patient. This special issue is dedicated to exploring biomarker-related and target-based research in chronic disease assessment, with a particular emphasis on cancer. We aim to showcase advances in molecular profiling, the application of omics technologies, and translational studies that bridge basic and clinical research. We welcome contributions addressing the challenges and opportunities in implementing personalized therapeutic strategies and emphasizing their practical applications in managing chronic diseases. Through this multidisciplinary approach, we aim to highlight the latest findings that support patient-centered interventions, ultimately advancing precision medicine in chronic disease management.

Dr. Luigi Sapio and Dr. Angela Ragone
Guest Editors

Manuscripts should be submitted via our online editorial system at https://www.discovmed.com/Journalx_dm/authorLogOn.action by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. Submitted manuscripts should be well formatted in good English.