Submission Deadline: 31 July 2025 (Status: Open)
Special Issue Editor(s)
Prof. Lei Huang
Email
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Website
Department of Molecular Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA
Interests:
cell metabolism; cancer biology; obesity; diabetes; cell apoptosis; cancer therapy; cell signaling; mitochondrial function; aging; metastasis; invasion; EMT; TME
Prof. Mengdie Feng
Email
|
Website
Nakada Lab, Baylor college ofMedicine, Houston, TX, USA
Interests:
human molecular; genetic
Special Issue Information
Dear Colleagues,
Cancer metabolism is characterized by altered energy production pathways that support the rapid growth and survival of tumor cells. Unlike normal cells, cancer cells often rely on aerobic glycolysis, known as the Warburg effect, even in the presence of oxygen. This metabolic reprogramming enables cancer cells to sustain their growth under nutrient-limited conditions. Recent studies have shown that these metabolic changes also profoundly affect the tumor microenvironment, particularly in shaping immune cell function. Immunotherapy, a groundbreaking approach to cancer treatment, enhances the body’s immune system to target and eliminate cancer cells. However, the efficacy of immunotherapy is often limited by the immunosuppressive tumor microenvironment, where cancer cells alter the metabolism of immune cells, leading to immune exhaustion and resistance to treatment. This proposal aims to investigate how the unique metabolic pathways in cancer cells influence the effectiveness of immunotherapy. By understanding the metabolic crosstalk between tumor cells and immune cells, this topic seeks to identify potential metabolic targets that could be modulated to improve the success of immunotherapies, such as checkpoint inhibitors and CAR-T cell therapy.
Key Questions
1. How does cancer metabolism contribute to the immune escape mechanisms in the tumor microenvironment?
2. Can metabolic reprogramming of immune cells enhance their anti-tumor activity during immunotherapy?
3. What metabolic targets can be identified to synergize with existing immunotherapies for improved outcomes?
Prof. Lei Huang and Prof. Mengdie Feng
Guest Editors
Keywords
cancer metabolism; immunotherapy; checkpoint; tumor microenvironment; immune cells; metabolic targets; multi-omics
Manuscript Submission Information
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