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Immunomodulators as Adjuvant Therapies in Cancer
Editor: Yamixa Delgado

Submission Deadline: 1 March 2025 (Status: Open)


Special Issue Editor(s)


Dr. Yamixa Delgado      Email   |   Website
San Juan Bautista School of Medicine, Caguas, Puerto Rico
Interests: cancer therapeutics; chemoresistance; immunotherapeutics; metastasis; drug delivery systems; natural products; epilepsy therapy; epileptogenesis; inflammation; plasticity


Special Issue Information

Dear Colleagues,

Despite the significant advances in cancer treatment attained in recent years, challenges such as drug resistance and adverse side effects continue to plague the therapeutic efforts. Nevertheless, the incorporation of immunomodulators stands out to be a promising strategy for enhancing the efficacy and safety of conventional cancer treatments. The objective of this special issue is to explore the potential of immunomodulators as adjuvant therapies to improve cancer outcomes.

This special issue welcomes submissions that examine the mechanisms influencing immunological pathways and enhancing anti-tumor immunity. Additionally, we invite contributions that examine the potential of immunomodulatory compounds that act synergistically with standard cancer therapies. Topics of interest include, but are not limited to, the identification of novel immunomodulators, their effects on immune cells and immune-related mechanisms (e.g., inflammatory markers), and translational studies evaluating their therapeutic potential. By convening leading experts in this field, this special issue is primed to advance our understanding of how to effectively enhance immune response by incorporating immunomodulators into standard cancer treatment regimens.

Dr. Yamixa Delgado
Guest Editor


Keywords

immunomodulators; cancer; immune response; adjuvant therapies; anti-tumor immunity; immunotherapeutics


Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at https://www.discovmed.com/Journalx_dm/authorLogOn.action by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. Submitted manuscripts should be well formatted in good English.

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    Caterina Gagliano, Roberta Foti, Elisa Visalli, Edoardo Dammino, Antonino Maniaci, Riccardo Foti, Dalila Incognito, Rosario Foti, Marco Zeppieri
    Discovery Medicine. 2024, 36(191): 2333-2342. https://doi.org/10.24976/Discov.Med.202436191.215

    The introduction of immunomodulators as adjuvant therapies in cancer treatment has represented a significant advancement in oncology, improving therapeutic response and patient survival. Emerging targets and molecules could provide new therapeutic opportunities for cancer patients. However, these agents can induce immunological side effects, including vasculitis and connective tissue diseases, which, while uncommon, present significant clinical challenges. This review analyzes the prevalence, clinical characteristics, therapeutic strategies, and management difficulties of vasculitis and connective tissue disorders triggered by immunomodulators in the context of cancer treatment. Although rare, these conditions significantly impact patients, demanding thorough management. Common rheumatological immune-related adverse events include inflammatory arthritis, Sjogren's disease, systemic lupus erythematosus, and systemic sclerosis, all of which require prompt recognition and appropriate intervention. Treatment frequently includes corticosteroids and immunosuppressive drugs, with new alternatives currently accessible. Efficient coordination between oncologists and rheumatologists enhances patient outcomes, highlighting the necessity for organized multidisciplinary strategies. Future research initiatives emphasize the identification of biomarkers for early diagnosis and the development of preventive methods to reduce immune-related adverse events in cancer therapy.